IMPCSF: Immunological mechanisms of protection against classical swine fever virus: towards the development of new efficacious marker vaccines

• Research unit: EU RFP
• Project number: 00.0635

Key words (English)

Classical swine fever; immunological mechanisms; innate immunity; marker vaccine;
Life Sciences; Medicine; Health; Safety; Scientific Research; Social Aspects

Alternative project number (English)

EU project number: QLK2-CT-2001-01374

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.2 Control of infectious diseases

Short description (English)

See abstract

Further information (English)

Full name of research-institution/enterprise:
Bundesamt für Veterinärwesen BVET
Institut für Viruskrankheiten und Immunprophylaxe

Partners and International Organizations (English)

Coordinator: ID-Lelystad Instituut (NL)

Abstract (English)

The high costs of an Classical Swine Fever (CSF) -outbreak, the social impact and resistance against destruction of pigs have led to reconsideration of emergency vaccination against CSF. The application of marker vaccines that can provide early protection might contribute to improved intervention and control strategies and might limit the duration and costs of an outbreak.

The objective of this project is to understand the immune mechanisms underlying protection against CSF, in particular the mechanisms involved in early protection against clinical signs of CSF and in the reduction of (horizontal) virus transmission.
The knowledge about relevant viral components, and about the quality of the vaccine-induce immune response may contribute to the future development of new and safe marker vaccines that can induce a fast protective immune response.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0635