EUROME: From the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis

• Unité de recherche: PCRD EU
• Numéro de projet: 00.0520
• Titre du projet anglais: EUROME: From the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis

Mots-clé (Anglais)

RA; K/BxN; GPI;
Life Sciences; Medicine; Health; Scientific Research

Autre Numéro de projet (Anglais)

EU project number: QLG1-CT-2001-01407

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.8 Generic R&D activities

Description succincte (Anglais)

See abstract

Autres indications (Anglais)

Full name of research-institution/enterprise:
Biotechnologie Institut Thurgau an der Universität Konstanz

Partenaires et organisations internationales (Anglais)

Coordinator: University of Rostock (D)

Résumé des résultats (Abstract) (Anglais)

The research network, EUROME, represents Centres of Excellence in Europe where recent technologies in transcriptome (microarrays) as well as proteome analysis are applied to study with the use of transgenic and congenic animal models human autoimmune diseases primarily rheumatoid arthritis (RA).
Susceptibility genes for autoimmune diseases are identified and their functions are determined. Targets for studying novel treatments are evaluated e.g. to stop neo angio-genesis in inflamed tissues. Gene and cell based intervention strategies are investigated to treat autoimmune diseases (rheumatoid arthritis). Common mechanisms that cause autoimmune diseases are determined. EUROM research leads to a genome-base individualized medicine.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0520