EUROME: From the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis

• Research unit: EU RFP
• Project number: 00.0520

Key words (English)

RA; K/BxN; GPI;
Life Sciences; Medicine; Health; Scientific Research

Alternative project number (English)

EU project number: QLG1-CT-2001-01407

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.8 Generic R&D activities

Short description (English)

See abstract

Further information (English)

Full name of research-institution/enterprise:
Biotechnologie Institut Thurgau an der Universität Konstanz

Partners and International Organizations (English)

Coordinator: University of Rostock (D)

Abstract (English)

The research network, EUROME, represents Centres of Excellence in Europe where recent technologies in transcriptome (microarrays) as well as proteome analysis are applied to study with the use of transgenic and congenic animal models human autoimmune diseases primarily rheumatoid arthritis (RA).
Susceptibility genes for autoimmune diseases are identified and their functions are determined. Targets for studying novel treatments are evaluated e.g. to stop neo angio-genesis in inflamed tissues. Gene and cell based intervention strategies are investigated to treat autoimmune diseases (rheumatoid arthritis). Common mechanisms that cause autoimmune diseases are determined. EUROM research leads to a genome-base individualized medicine.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0520