IMPAD: Improved healthcare for patients with primary antibody deficiencies through new strategies eludating their pathophysiology

• Unité de recherche: PCRD EU
• Numéro de projet: 00.0502
• Titre du projet anglais: IMPAD: Improved healthcare for patients with primary antibody deficiencies through new strategies eludating their pathophysiology

Mots-clé (Anglais)

Pure sCO21; B-cells;
Life Sciences; Medicine; Health; Scientific Research

Autre Numéro de projet (Anglais)

EU project number: QLG1-CT-2001-01536

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.8 Generic R&D activities

Description succincte (Anglais)

See abstract

Autres indications (Anglais)

Full name of research-institution/enterprise:
Biotechnologie Institut Thurgau an der Universität Konstanz

Partenaires et organisations internationales (Anglais)

Coordinator: Universitätsklinik Freiburg (D)

Résumé des résultats (Abstract) (Anglais)

Primary antibody deficiencies like common variable immunodeficiency, IgA-deficiency and the non-X-linked hyper-IgM syndrome are rare, chronic diseases that are severely complicated by recurrent bacterial infections, poorly recognized in daily medical practice and expensive to treat.
To understand their unknown aetiologies, our multidsciplinary approach combines 10 European groups to identify the genetic origins of the deficiencies, the genetic risk factors in different European populations, the defects and changes in inter- and intracellular signalling pathways and their pathophysiological relations to immunological phenotypes and function.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0502