PLANTREC: Homologous recombination in plants

• Unité de recherche: PCRD EU
• Numéro de projet: 01.0184
• Titre du projet anglais: PLANTREC: Homologous recombination in plants

Mots-clé (Anglais)

Hyper-recombinogenic mutants; expression profiling; gene targeting;
Biotechnology; Life Sciences; Medicine; Health; Scientific Research

Autre Numéro de projet (Anglais)

EU project number: QLG2-CT-2001-01397

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.8 Generic R&D activities

Description succincte (Anglais)

See abstract

Partenaires et organisations internationales (Anglais)

Coordinator:

Résumé des résultats (Abstract) (Anglais)

Major advances have been made in knowledge of plant genomes and the recombination processes regulating their structure and integrity.
However, exploitation of this is limited by absence of methodology for the targeted, in-situ modification of plant genes and chromosomes. In plants the somatic homologous recombination machinery is overwhelmed by another recombination process (NHEJ), which causes incoming DNA to insert at a random position in the genome, often accompanied by un wanted rearrangements.
This is an important reason for questioning the safety of transgenic crops. We directly address these issues and 5 academic and 2 industrial research groups together aim to develop novel tools to obtain gene targeting in plants, based on a detailed understanding of recombination in plants.
The groups will contribute considerable novel expertise and biological material to the project: plant hype recombination mutants, cloned genes and proven assays.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 01.0184