LEISHNATDRUG-R: Molecular tools for monitoring emergence and spreading of drug resistance among natural population of leishmania

• Unité de recherche: PCRD EU
• Numéro de projet: 01.0089
• Titre du projet anglais: LEISHNATDRUG-R: Molecular tools for monitoring emergence and spreading of drug resistance among natural population of leishmania

Mots-clé (Anglais)

Leishmania; drug resistance; antimonials;
Coordination; Cooperation; Economic Aspects; Scientific Research

Autre Numéro de projet (Anglais)

EU project number: ICA4-2001-10076

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 2.3 Developing countries

Description succincte (Anglais)

See abstract

Autres indications (Anglais)

Full name of research-institution/enterprise:
Hôpitaux universitaires de Genève HUG
Département de médecine communautaire
Unité de médecine des voyages et migrations

Partenaires et organisations internationales (Anglais)

Coordinator: Prins Leopold Instituut, Antwerpen (B)

Résumé des résultats (Abstract) (Anglais)

Leishmaniasis is a severe health problem in DCs and Europe. Pentavalent antimonials (SbV)will remain the first line drug for the forthcoming years. Control is being challenged by increased SbV resistance. Our aim is to desig molecular tools for detecting emergence and spreading of drug resistance in visceral and mucocutaneous leishmaniases. To achieve this, we will obtain samples from SbV susceptible and refractory patients (Nepal, Bolivia, Peru ), identify molecular modifications associated with SbV resistance in FIELD isolates, transfer this Knowledge into molecular tools for drug resistance diagnosis, and define the population structure of sensitive and resistant isolates for understanding the epidemiological dynamics of drug resistance.

Outputs:
- collection of naturally resistant parasites;
- knowledge on natural mechanisms generating SbV resistance and its transmission;
- PCR tools for preventing therapeutic failure and guidelines for their use in epidemiological surveillance.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 01.0089