VirRNApoldrugtarget: Towards the design of new potent antiviral drugs: structure-function analysis of paramyxoviridae RNA polymerase

• Unité de recherche: PCRD EU
• Numéro de projet: 01.0070
• Titre du projet anglais: VirRNApoldrugtarget: Towards the design of new potent antiviral drugs: structure-function analysis of paramyxoviridae RNA polymerase

Mots-clé (Anglais)

Paramyxovirus; Sendai virus; RNA polymerase; nucleocapsid; replication;
Life Sciences; Medicine; Health; Safety; Scientific Research; Social Aspects

Autre Numéro de projet (Anglais)

EU project number: QLK2-CT-2001-01225

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.2 Control of infectious diseases

Description succincte (Anglais)

See abstract

Autres indications (Anglais)

Full name of research-institution/enterprise:
Université de Genève
Centre Médical Universitaire
Département de Microbiologie et Médecine Moléculaire

Partenaires et organisations internationales (Anglais)

Coordinator: Université Claude Bernard, Lyon (F)

Résumé des résultats (Abstract) (Anglais)

The ultimate goal is the design of new antiviral drugs that specifically interfere with the replication of virus members of the Mononegavirales order, which are responsible for human and animal life-threatening diseases with large socio-economic impact. The RNA-dependent RNA-polymerase (RdRp) of these viruses, the replicase, has no counterpart in mammalian cells, what makes it an attractive target for antiviral therapy.

Seven partners will perform a structure-function analysis of the replicase, its viral, and possibly cellular, cofactors, and of its unique template, the nucleo-capsid, in the presence or absence of antiviral drugs.
To increase the chance of success, three complementary virus models will be studied, the Measles, Respiratory Syncytial & Sendai viruses. The outcome will be a 'poly-merase toolbox' which will enable a panel of 5 European SME to model the replicase and its template from any related viruses and design new antiviral drugs & vaccine.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 01.0070