EFFICACIOUS DELIVERY: Identification of efficacious delivery systems for recombinant and nucleic acid construct vaccines

• Research unit: EU RFP
• Project number: 00.0636

Key words (English)

Classical swine fever; novel-type vaccine; immune response; immunostimulation;
Life Sciences; Medicine; Health; Safety; Scientific Research; Social Aspects

Alternative project number (English)

EU project number: QLK2-CT-2001-01346

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.2 Control of infectious diseases

Short description (English)

See abstract

Further information (English)

Full name of research-institution/enterprise:
Bundesamt für Veterinärwesen BVET
Institut für Viruskrankheiten u. Immunprophylaxe IVI
Sektion Immunologie

Partners and International Organizations (English)

Coordinator: Federal Research Centre for Virus (D)

Abstract (English)

Classical swine fever virus (CSFV) is a well suited model for the evaluation of protective immunity in swine induced by virus subunits.

Novel vaccines, which are investigated in this project, can be divided into two groups:
1. viral subunit antigens generated in vitro and;
2. DNA- or RNA-based delivery systems and paradox virus-based expression system, producing the relevant antigens in vivo.

In addition the modification of such vaccines with potent immuno-modulatory molecules and loading of dendrite cells (DC) will be tested for improving immuno-stimulatory effects in swine. Since only highly efficacious vaccines are responsible for a rapid onset of protection in naive animal populations this study will focus on the immune response after primary vaccination. The results of the study will provide sufficient information to be able to identify efficient vaccine-types against CSFV as well as other emerging diseases.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0636