SGT in SCT: Suicide gene therapy in stem cell transplantation

• Unité de recherche: PCRD EU
• Numéro de projet: 00.0614
• Titre du projet anglais: SGT in SCT: Suicide gene therapy in stem cell transplantation

Mots-clé (Anglais)

Suicide gene therapy; stem cells; humanized herpes simplex virus thymidine kinase; ganciclovir; (N)-methanocarbathymidine;
Biotechnology; Environmental Protection; Innovation; Technology Transfer; Life Sciences; Medicine; Health; Waste Management

Autre Numéro de projet (Anglais)

EU project number: QLK3-CT-2001-01265

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.3 The 'cell factory'

Description succincte (Anglais)

See abstract

Autres indications (Anglais)

Full name of research-institution/enterprise:
ETH Zürich
Institut für Pharmazeut. Wissenschaften

Partenaires et organisations internationales (Anglais)

Coordinator: Fondazione Centro San Raffaele, Milano (I)

Résumé des résultats (Abstract) (Anglais)

The outcome of allogeneic stem cell transplantation (allo-SCT), the treatment for haematological malignancies, is significantly limited by a severe and potentially life-threatening complication induced by donor lymphocytes, i.e. graft-vs-host disease (GvHD). The aim of this 3 year pre-competitive project is the development, pre-clinical evaluation and exploitation in the clinical setting of an innovative therapeutic strategy for the transfer into donor lymphocytes of a suicide gene-conferring sensitivity to a pro-drug thus allowing their subsequent selective in-vivo elimination and cure of GvHD.

New suicide and marker genes, viral vectors and protocols for cell manipulation will be developed and rapidly transferred to industrial partners to prepare the exploitation in the clinical setting. Finally, clinical protocols using this strategy will be developed with the final goal of offering safer and more effective allo-SCT to a larger number of patients.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0614