HCVacc-Strat.: Vaccine delivery systems for the development of preventive or therapeutic interventions against hepatitis C

• Research unit: EU RFP
• Project number: 99.0672-1

Key words (English)

Life Sciences; Medicine; Health; Safety; Scientific Research; Social Aspects; hepatitis C virus; HCV vaccine; animal model for HCV; HCV replication; HCV envelop; HCV structural proteins; HCV cytotoxic epitopes

Alternative project number (English)

EU project number: QLK2-1999-00356

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.2 Control of infectious diseases

Short description (English)

See abstract

Partners and International Organizations (English)

Coordinator: INSERM, Lyon (F)

Abstract (English)

The overall objective of this cluster is to contribute to the development of preventive and therapeutic vaccines against hepatitis C virus (HCV) infection. For this objective an in depth understanding of protective antiviral immune response s is essential by acquiring knowledge on mechanisms associated with HCV replication, assembly and fundamental knowledge on HCV specific immune responses in natural infections. A key element in the development of a vaccine is the choice of a delivery system capable to induce a humoral and/or a cellular-mediated protective immune response. The networks in this cluster proposal have strong, worldwide-recognized expertise and have all parameters to monitor the planned analysis from fundamental in vitro studies to the evaluation of vaccine candidates in non-human primates. The basic strength of the Cluster is to re-unite expertise and unique systems that will allow a solid basis for the definition of clinical trials.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 99.0672-1