BASECONV: Therapeutic substances for in vivo targeted gene modification

• Unité de recherche: PCRD EU
• Numéro de projet: 00.0641
• Titre du projet anglais: BASECONV: Therapeutic substances for in vivo targeted gene modification

Mots-clé (Anglais)

Gene therapy; DNA repair; gene targeting; oligonucleotides;
Biotechnology; Environmental Protection; Innovation; Technology Transfer; Life Sciences; Medicine; Health; Waste Management

Autre Numéro de projet (Anglais)

EU project number: 3QLK3-2000-00634

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.3 The 'cell factory'

Description succincte (Anglais)

See abstract

Autres indications (Anglais)

Full name of research-institution/enterprise:
Universität Zürich
Institut für Medizinische Radiobiologie

Partenaires et organisations internationales (Anglais)

Coordinator: University of Oslo (S)

Résumé des résultats (Abstract) (Anglais)

We work towards a platform technology that allows high efficiency targeted gene modification, including repair of mutated genes in the genome of humans but also site specific mutagenesis in living cells at will. For this aim we develop a novel class of sequence specific bioactive molecules: Therapeutic Repair Oligomers (TROs). TROs are able to recognize a particular DNA sequence and to induce specific sequence changes. The outcome of our research will have profound implications for human gene therapy by eliminating the need of introducing foreign genes. For plant breeding the platform technology will have the potential of creating new consumer friendly traits based on single point mutations.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0641