BASECONV: Therapeutic substances for in vivo targeted gene modification

• Research unit: EU RFP
• Project number: 00.0641

Key words (English)

Gene therapy; DNA repair; gene targeting; oligonucleotides;
Biotechnology; Environmental Protection; Innovation; Technology Transfer; Life Sciences; Medicine; Health; Waste Management

Alternative project number (English)

EU project number: 3QLK3-2000-00634

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.3 The 'cell factory'

Short description (English)

See abstract

Further information (English)

Full name of research-institution/enterprise:
Universität Zürich
Institut für Medizinische Radiobiologie

Partners and International Organizations (English)

Coordinator: University of Oslo (S)

Abstract (English)

We work towards a platform technology that allows high efficiency targeted gene modification, including repair of mutated genes in the genome of humans but also site specific mutagenesis in living cells at will. For this aim we develop a novel class of sequence specific bioactive molecules: Therapeutic Repair Oligomers (TROs). TROs are able to recognize a particular DNA sequence and to induce specific sequence changes. The outcome of our research will have profound implications for human gene therapy by eliminating the need of introducing foreign genes. For plant breeding the platform technology will have the potential of creating new consumer friendly traits based on single point mutations.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0641