ENFET: European Network for Fetal Transplantation

• Research unit: EU RFP
• Project number: 00.0625

Key words (English)

In-utero transplantation; hematopoietic stem cells; fetal cells;
Life Sciences; Medicine; Health; Scientific Research

Alternative project number (English)

EU project number: QLG1-2000-01475

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.8 Generic R&D activities

Short description (English)

See abstract

Further information (English)

Full name of research-institution/enterprise:
Universitäts-Frauenklinik Kantonsspital Basel

Partners and International Organizations (English)

Coordinator: University of Nottingham (UK)

Abstract (English)

In uterus stem cell transplantation is a novel therapy targeted at the fetus, within the uterus early in a pregnancy. This therapy is intended to treat a genetic disorder, diagnosed within the first 12 weeks of gestation, before the pathological effects become manifested. Currently, there are some successful cases reported and European centres are in a leading position in the field. However, there is a pressing need for consensus in many aspects of this therapy and a consortium of European centres with expertise in many areas of stem cells and transplantation will be uniquely placed to ensure that the in utero procedure can be used to maximum benefit.

The successful transplantation of stem cells into a recipient fetus wile in utero, in order to prevent the serous pathological effects of a genetic disorder, diagnosed in prenatal life. The establishment of audited protocols, which ensure the safety and the efficacy of the procedure. The establishment of cell banks, in centre throughout Europe, which are specifically intended to furnish cells appropriate for the in utero-transplant procedure. Publication of recommendations and guidelines to assist those intending to use the procedure. This aspect of the programme will encompass gene-therapy protocols.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0625