NEUROSTEROIDS & AGEING: The role of neurosteroids in healthy ageing : therapeutical perspectives

• Unité de recherche: PCRD EU
• Numéro de projet: 00.0407
• Titre du projet anglais: NEUROSTEROIDS & AGEING: The role of neurosteroids in healthy ageing : therapeutical perspectives

Mots-clé (Anglais)

Neurosteroids; myelin; gene regulation; Life Sciences; Medicine; Health; Social Aspects

Autre Numéro de projet (Anglais)

EU project number: QLK6-2000-00179

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.6 The ageing population and disabilities

Description succincte (Anglais)

See abstract

Partenaires et organisations internationales (Anglais)

Coordinator: National Institut de la Sante et de la Recherche (F)

Résumé des résultats (Abstract) (Anglais)

Extensive death of nerve cells may no longer be considered as a major event in t he process of normal ageing of the nervous system (except in pathological conditions). In addition, the ageing brain and nerves retain sufficient plasticity for regeneration. This means that treating normal age-related dysfunctions of the nervous system, such as memory loss, will become possible. Indeed, research carried out in the laboratories of the partners has shown that age-related memory deficits and abnormalities of myelin sheaths (which isolate nerve fibres) can be reversed by the administration of neurosteroids (steroids which can be locally synthesised in the nervous system).

Two complementary therapeutic strategies will be explored:
1) Increasing the local synthesis of neurosteroids by agonists of the mitochondrial benzodiazepine receptor;
2) administering selective neurosteroid compounds.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0407