Molecular Signalling: Disease insights from single cell signaling

• Research unit: EU RFP
• Project number: 00.0333

Key words (English)

Insulin; signaling; disease; kinase;
Biotechnology; Environmental Protection; Innovation; Technology Transfer; Life Sciences; Medicine; Health; Waste Management

Alternative project number (English)

EU project number: QLK3-2000-01038

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.3 The 'cell factory'

Short description (English)

See abstract

Partners and International Organizations (English)

Coordinator: Centre National de la Recherche Scientifique CNRS (F)

Abstract (English)

Signalling cascades play multiple roles in cell growth, differentiation and death. Their perturbation has profound consequences linked to diseases such as cancer, myopathy and diabetes, major health concerns in Europe. We propose to develop and implement nano-technologies, which allow monitoring and examination of intracellular signalling processes in real time at the single cell level. Our goals are to create detailed molecular maps of the temporal and spatial organization of proteins involved in signal transduction, in particular insulin signalling. With this information we can compare diseased and normal tissue to identify specific errors in signalling cascades. Moreover, we can directly develop non-animal based assays for use in drug discovery. Once established this nanotechnology can be extended to the analysis of diverse signalling cassettes in a variety of other diseases of high social and economic impact in Europe.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0333