Partner und Internationale Organisationen
(Englisch)
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A, B, HR, CZ, DK, FIN, F, D, GR, H, IRL, I, NL, PL, P, RO, SI, E, S, CH, GB
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Abstract
(Englisch)
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Non-covalent cation-p interactions play an important role in building up the structure of many biologically important macromolecules and in promoting fundamental functions such as recognition, transport and chemical transformation of a bound substrate. These interactions, occurring for instance between quaternary ammonium / pyridinium cations and aromatic residues are crucial in many systems and are the domain of investigation of this COST D11 workgroup. For our purpose, the cation is often chiral and the question of the stereoselective recognition by chiral hosts become debatable. For the past year, we have tackled a study on the interactions of quaternary ammonium or pyridinium cations and novel chiral hexacoordinated phosphates. 1. Solid-state studies were performed on the association of tetraalkylammonium cations and D3-symmetric TRISPHAT anions (Jyväskylä and Geneva groups; results to be submitted as part of an article on TRISPHAT). 2. Interactions between chiral phosphates and C2-symmetric configurationally labile diquats were performed and a stereoselective induction observed (Roma and Geneva groups; 1 publication). 3. Discriminating interactions occurring between various chiral anions from our group and chiral quaternary ammonium cations were studied and led to the discovery that only one anion (BIMPHAT) leads to strong enantiodifferentiations in NMR (2 publications). Samples of the derived salts were sent to the Mainz and Düsseldorf groups for studies with the chiral hosts developed by them (Düsseldorf and Geneva: 1 publication).
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