CBPPVAC: Development of an improved vaccine against contagious bovine pleuropneumonia

• Research unit: EU RFP
• Project number: 99.0849

Key words (English)

CBPP vaccine; lipoprotein; ABC transporter; adhesin;
Coordination; Cooperation; Economic Aspects; Scientific Research

Alternative project number (English)

EU project number: ICA4-2000-30015

Research programs (English)

EU-programme: 5. Frame Research Programme - 2.3 Developing countries

Short description (English)

See abstract

Further information (English)

Full name of research-institution/enterprise:
Universität Bern
Institut für Veterinär-Bakteriologie

Partners and International Organizations (English)

CIRAD-EMVT, Montpellier (F), Laboratório Nacional de Investigação Veterinária, Lisboa (P), Agricultural Research Council, Pretoria (ZA), Laboratoire Central Vétérianire, Bamako (ML)

Abstract (English)

Contagious bovine pleuropneumonia (CBPP) represents a major constraint to cattle raising in Africa. Its eradication is hampered by the low efficacy of the available vaccines. Therefore, development of an improved vaccine is the objective of this project. To achieve this aim, the protective immune response elicited in CBPP-recovered cattle and the pathogen components involved, will be characterised. The mechanisms and virulence factors responsible for pahogen/host cell interactions will be assessed. In vitro models for testing the safety of the selected immunogens will be developed. This study will define the cell subsets, cytokines and immunoglobulins involved in protection and, safe and efficient immunogens as vaccine candidates. These data will determine the appropriate vaccinal strategies against CBPP.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 99.0849