EUSAFEVAC: European research programme for improved vaccine safety surveillance

• Research unit: EU RFP
• Project number: 99.0818

Key words (English)

Vaccines; immunization; safety; adverse events following immunization;
Life Sciences; Medicine; Health; Scientific Research; Social Aspects

Alternative project number (English)

EU project number: QLG4-2000-00612

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.2 Control of infectious diseases

Short description (English)

See abstract

Further information (English)

Full name of research-institution/enterprise:
Universitäts-Kinderspital beider Basel
Infektologie und Vakzinologie

Partners and International Organizations (English)

Coordinator: Swedish Institute for Infectous Disease Control (S)

Abstract (English)

The overall objective is to provide a scientific basis for improved vaccine safety surveillance.

Problems in current passive reporting systems will be explored;
Further objectives include development of case definitions for Adverse Events Following Immunization (AEFI);
production of guidelines for data collection;
development of a vaccine register model;
comparisons of active and passive surveillance;
and production of training materials.

Work plan: A systematic review of AEFIs after MMR will be performed. Problems in the current passive reporting systems will be analysed utilizing recently compiled European database. Expert groups will develop case definitions for significant AEFI, and the definitions will be validated. Essential properties of vaccine registers will be analysed. The conclusions from these achievements will be used in a prospective study of active and passive reporting systems. All results will be combined in an analytic overview, and also used for electronic training materials directed to professionals in vaccino-vigilance.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 99.0818