EUROCARINII: Human pneumocystis carinii infection in immunocompetent hosts - a public health issue in Europe

• Research unit: EU RFP
• Project number: 00.0021

Key words (English)

Prevalence; carriage; chronic bronchial disease; pneumocystis carinii epidemiology ;
Life Sciences; Medicine; Health; Safety; Scientific Research; Social Aspects

Alternative project number (English)

EU project number: QLRH-1999-31360

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.2 Control of infectious diseases

Short description (French)

Veuillez consulter l'abstract

Further information (English)

Full name of research-institution/enterprise:
Centre hospitalier universitaire vaudois CHUV
Division de Médecine Préventive Hospitalière

Partners and International Organizations (French)

Coordinator: Servicio Andaluz de Salud, Sevilla (E)

Abstract (French)

This project is the first multicenter study on subclinical P. carinii (PC) infection in the general population, in which genotypical, phenotypical and clinical aspects are combined in order to assess its importance for public health. General objective: to provide new knowledge on the epidemiology and the clinical impact of PC-infection in Europe.

Specific objectives:
1)To investigate the prevalence of PC subclinical infection in subjects with chronic bronchial disease and in healthy individuals from Europe and its correlation with environmental factors;
2) To draw an epidemiological map of PC genotypes;
3) To explore genomic and phenotypic differences between PC from carriers and from PC pneumonia patients;
4) To characterise the immune response against PC infection in subjects which develop pneumonia, remain as carriers or eliminate the infection;
5) Defining the role of immunological mechanisms of protection against human PC infection;
6) Definition of the role of the PC infection in the evolution of CBD and the role of PC carriers in the parasite transmission.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0021