EUROCARINII: Human pneumocystis carinii infection in immunocompetent hosts - a public health issue in Europe

• Forschungsstelle: EU FRP
• Projektnummer: 00.0021
• Projekttitel Englisch: EUROCARINII: Human pneumocystis carinii infection in immunocompetent hosts - a public health issue in Europe

Schlüsselwörter (Englisch)

Prevalence; carriage; chronic bronchial disease; pneumocystis carinii epidemiology ;
Life Sciences; Medicine; Health; Safety; Scientific Research; Social Aspects

Alternative Projektnummern (Englisch)

EU project number: QLRH-1999-31360

Forschungsprogramme (Englisch)

EU-programme: 5. Frame Research Programme - 1.1.2 Control of infectious diseases

Kurzbeschreibung (Französisch)

Veuillez consulter l'abstract

Weitere Hinweise und Angaben (Englisch)

Full name of research-institution/enterprise:
Centre hospitalier universitaire vaudois CHUV
Division de Médecine Préventive Hospitalière

Partner und Internationale Organisationen (Französisch)

Coordinator: Servicio Andaluz de Salud, Sevilla (E)

Abstract (Französisch)

This project is the first multicenter study on subclinical P. carinii (PC) infection in the general population, in which genotypical, phenotypical and clinical aspects are combined in order to assess its importance for public health. General objective: to provide new knowledge on the epidemiology and the clinical impact of PC-infection in Europe.

Specific objectives:
1)To investigate the prevalence of PC subclinical infection in subjects with chronic bronchial disease and in healthy individuals from Europe and its correlation with environmental factors;
2) To draw an epidemiological map of PC genotypes;
3) To explore genomic and phenotypic differences between PC from carriers and from PC pneumonia patients;
4) To characterise the immune response against PC infection in subjects which develop pneumonia, remain as carriers or eliminate the infection;
5) Defining the role of immunological mechanisms of protection against human PC infection;
6) Definition of the role of the PC infection in the evolution of CBD and the role of PC carriers in the parasite transmission.

Datenbankreferenzen (Englisch)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0021